Complete Guide to Uterine Cancer Prevention for Patients
Endometrial Cancer Prevention
What is prevention?
Cancer prevention is action taken to lower the chance of getting cancer. By preventing cancer, the number of new cases of cancer in a group or population is lowered. Hopefully, this will lower the number of deaths caused by cancer.
To prevent new cancers from starting, scientists look at risk factors and protective factors. Anything that increases your chance of developing cancer is called a cancer risk factor; anything that decreases your chance of developing cancer is called a cancer protective factor.
Some risk factors for cancer can be avoided, but many cannot. For example, both smoking and inheriting certain genes are risk factors for some types of cancer, but only smoking can be avoided. Regular exercise and a healthy diet may be protective factors for some types of cancer. Avoiding risk factors and increasing protective factors may lower your risk but it does not mean that you will not get cancer.
Different ways to prevent cancer are being studied.
General Information About Endometrial Cancer
Key Points
- Endometrial cancer is a disease in which malignant (cancer) cells form in the tissues of the endometrium.
- Endometrial cancer is most common in postmenopausal women.
Endometrial cancer is a disease in which malignant (cancer) cells form in the tissues of the endometrium.
The endometrium is the lining of the uterus. The uterus is part of the female reproductive system. It is a hollow, pear-shaped, muscular organ in the pelvis, where a fetus grows.
Cancer of the endometrium is different from cancer of the muscle of the uterus, which is called sarcoma of the uterus. See the PDQ summary on Uterine Sarcoma Treatment for more information.
See the following PDQ summaries for more information about endometrial cancer:
Endometrial cancer is most common in postmenopausal women.
Endometrial cancer is diagnosed most often in postmenopausal women at an average age of 60 years.
Since the mid-2000s, the number of new cases of endometrial cancer has increased slightly each year. From 2015 to 2019, the number of deaths from endometrial cancer increased by about 1% per year.
Endometrial Cancer Prevention
Key Points
- Avoiding risk factors and increasing protective factors may help prevent cancer.
- The following risk factors increase the risk of endometrial cancer:
- Endometrial hyperplasia
- Estrogen
- Tamoxifen
- Obesity, weight gain, metabolic syndrome, and diabetes
- Genetic factors
- The following protective factors decrease the risk of endometrial cancer:
- Pregnancy and breast-feeding
- Hormonal contraceptives
- Weight loss
- Physical activity
- It is not known if the following factors affect the risk of endometrial cancer:
- Fruits, vegetables, and vitamins
- Hair products, including dyes, bleach, highlights, straighteners, and permanents
- Cancer prevention clinical trials are used to study ways to prevent cancer.
- New ways to prevent endometrial cancer are being studied in clinical trials.
Avoiding risk factors and increasing protective factors may help prevent cancer.
Avoiding cancer risk factors may help prevent certain cancers. Risk factors include smoking, being overweight, and not getting enough exercise. Increasing protective factors such as quitting smoking and exercising may also help prevent some cancers. Talk to your doctor or other healthcare professional about how you might lower your risk of cancer.
The following risk factors increase the risk of endometrial cancer:
Endometrial hyperplasia
Endometrial hyperplasia is an abnormal thickening of the endometrium (lining of the uterus). It is not cancer, but in some cases, it may lead to endometrial cancer.
Estrogen
Estrogen is a hormone made by the body. It helps the body develop and maintain female sex characteristics. Estrogen can affect the growth of some cancers, including endometrial cancer.
A woman's risk of developing endometrial cancer is increased by being exposed to estrogen in the following ways:
- Estrogen-only hormone therapy: Estrogen may be given to replace the estrogen no longer produced by the ovaries in postmenopausal women or women whose ovaries have been removed. This is called hormone therapy (HT). The use of HT that contains only estrogen increases the risk
of endometrial cancer, and the risk grows higher the longer the estrogen is used. For this reason, estrogen therapy alone is usually prescribed only for women who do not have a uterus.
When estrogen is combined with progestin (another hormone), it is called combination estrogen-progestin therapy. For postmenopausal women, taking estrogen in combination with progestin does not increase the risk of endometrial cancer, but it does increase the risk of breast cancer. (See the Breast Cancer Prevention summary for more information.)
- Early menstruation: Beginning to have menstrual periods at an early age increases the number of years the body is exposed to estrogen and increases a woman's risk of endometrial cancer.
- Late menopause: Women who reach menopause at an older age are exposed to estrogen for a longer time and have an increased risk of endometrial cancer.
- Never being pregnant: Because estrogen levels are lower during pregnancy, women who have never been pregnant are exposed to estrogen for a longer time than women who have been pregnant. This increases the risk of endometrial cancer.
Tamoxifen
Tamoxifen is one of a group of drugs called selective estrogen receptor modulators, or SERMs. Tamoxifen acts like estrogen on some tissues in the body, such as the uterus, but blocks the effects of estrogen on other tissues, such as the breast. Tamoxifen is used to prevent breast cancer in women who are at high risk for the disease. However, using tamoxifen for more than 2 years increases the risk of endometrial cancer. This risk is greater in postmenopausal women.
Raloxifene is a SERM that is used to prevent bone weakness in postmenopausal women. However, it does not have estrogen-like effects on the uterus and has not been shown to increase the risk of endometrial cancer.
Obesity, weight gain, metabolic syndrome, and diabetes
Obesity, gaining weight as an adult, or having metabolic syndrome increases the risk of endometrial cancer. Obesity is related to other risk factors such as high estrogen levels, having extra fat around the waist, polycystic ovary syndrome, and lack of physical activity.
Having metabolic syndrome increases the risk of endometrial cancer. Metabolic syndrome is a condition that includes extra fat around the waist, high blood sugar, high blood pressure, and high levels of triglycerides (a type of fat) in the blood.
Having type 2 diabetes may increase the risk of endometrial cancer.
Genetic factors
Based on solid evidence, women with certain genetic conditions have an increased risk of developing endometrial cancer.
Lynch syndrome is an inherited disorder caused by changes in certain genes. Women who have Lynch syndrome have a much higher risk of developing endometrial cancer than women who do not have Lynch syndrome.
Polycystic ovary syndrome (a disorder of the hormones made by the ovaries), and Cowden syndrome are inherited conditions that are linked to an increased risk of endometrial cancer.
Women with a family history of endometrial cancer in a first-degree relative (mother, sister, or daughter) are also at increased risk of endometrial cancer.
The following protective factors decrease the risk of endometrial cancer:
Pregnancy and breast-feeding
Estrogen levels are lower during pregnancy and when breast-feeding. The risk of endometrial cancer is lower in women who have had children. Breastfeeding also decreases the risk of endometrial cancer.
Hormonal contraceptives
Taking hormonal contraceptives (birth control pills) that combine estrogen and progestin (combined oral contraceptives) decreases the risk of endometrial cancer. The protective effect of this type of birth control increases with the length of time they are used, and can last for many years after oral contraceptive use has been stopped.
While taking birth control pills, women have a higher risk of blood clots, stroke, and heart attack, especially women who smoke and are older than 35 years.
New data suggest that other hormonal contraceptives, such as birth control devices that are inserted into a woman's uterus, may also decrease the risk of endometrial cancer.
Weight loss
It is not known if losing weight decreases the risk of endometrial cancer. However, having bariatric surgery (a surgery that changes how your digestive system works so you will lose weight) decreases the risk of endometrial cancer. After bariatric surgery, other obesity-related conditions, such as diabetes and metabolic syndrome often improve or go away.
Having bariatric surgery also includes risks, such as infection, blood clots, breathing or heart problems, and digestive issues.
Physical activity
Physical activity (exercise) may lower the risk of endometrial cancer. This includes any physical activity you do at your job or at home.
It is not known if the following factors affect the risk of endometrial cancer:
Fruits, vegetables, and vitamins
A diet that includes, fruits, vegetables, phytoestrogen, soy, and vitamin D has not been found to affect the risk of endometrial cancer.
Taking multivitamins has little or no effect on the risk of common cancers, including endometrial cancer.
Hair products, including dyes, bleach, highlights, straighteners, and permanents
There is not enough evidence to show a link between hair products and endometrial cancer. One retrospective study discussed a possible link between certain hair products and uterine cancers, including endometrial cancers.
Cancer prevention clinical trials are used to study ways to prevent cancer.
Cancer prevention clinical trials are used to study ways to lower the risk of developing certain types of cancer. Some cancer prevention trials are conducted with healthy people who have not had cancer but who have an increased risk for cancer. Other prevention trials are conducted with people who have had cancer and are trying to prevent another cancer of the same type or to lower their chance of developing a new type of cancer. Other trials are done with healthy volunteers who are not known to have any risk factors for cancer.
The purpose of some cancer prevention clinical trials is to find out whether actions people take can prevent cancer. These may include eating fruits and vegetables, exercising, quitting smoking, or taking certain medicines, vitamins, minerals, or food supplements.
New ways to prevent endometrial cancer are being studied in clinical trials.
Information about clinical trials supported by NCI can be found on NCI’s clinical trials search webpage. Clinical trials supported by other organizations can be found on the ClinicalTrials.gov website.
Updated: August 21, 2023
This content is provided by the National Cancer Institute.
Source URL: https://www.cancer.gov/types/uterine/patient/endometrial-prevention-pdq