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CIELO Study for Autoimmune Encephalitis

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A PHASE III, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER BASKET STUDY TO EVALUATE THE EFFICACY, SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SATRALIZUMAB IN PATIENTS WITH ANTI-N-METHYL-D-ASPARTIC ACID RECEPTOR (NMDAR) OR ANTI-LEUCINE-RICH GLIOMA-INACTIVATED 1 (LGI1) ENCEPHALITIS

  • Sex at Birth: Any
  • Age: Child (Birth - 17), Adult (18 - 64), Older Adult (65+)
  • Accepting Healthy People: No
  • Type: Interventional / Therapeutic
  • Trial Phase: Phase III
  • Conditions Being Studied: Brain and Nervous System, Encephalitis

Study Purpose

The purpose of this study is to assess the effects, good or bad, of satralizumab in participants with autoimmune encephalitis. You are being asked to take part in this research study (also known as a clinical trial) because you have autoimmune encephalitis, a disease where the body's immune system attacks the brain.

Who Can Participate

Age: 12 and older

Principal Investigator
Hesham Abboud MD
Department/Division
Neurology (Neuroimmunology / MS)

Locations

UH Minoff Health Center at Chagrin Highlands
3909 Orange Place
Orange Village OH, 44122

UH Suburban Health Center
1611 South Green Road
South Euclid OH, 44121

UH Cleveland Medical Center
11100 Euclid Avenue
Cleveland OH, 44106

  • UH IRB: STUDY20220926
  • StudyID: 2022-0853
  • ClinicalTrials.gov: NCT05503264
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