APOL1-mediated Proteinuric Kidney Disease

Study Purpose

This study is enrolling participants who may have APOL1-mediated Chronic Kidney Disease. This means you may have increased levels of protein in the urine because your kidneys are not working properly. This condition may or may not be attributed to having a genetic variation (changes in DNA) in a gene called APOL1. Certain people with variants in the APOL1 gene have a higher risk of kidney disease. People of recent African ancestry are more likely to have certain APOL1 variants and are more at risk for CKD. You may never have been tested for APOL1 and therefore do not know if your kidney disease is caused or affected by having the APOL1 variation. This study is being done to learn more about the safety and effectiveness of the investigational drug VX-147 in participants with APOL1-Mediated Chronic Kidney Disease.